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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Sarah Constantin‏ @s_r_constantin May 3
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      What ordinary lay humans care about — can this drug save lives? can it make #COVID19 close to harmless? — is not even being tested!!!

      1 reply 0 retweets 17 likes
      Show this thread
    2. Sarah Constantin‏ @s_r_constantin May 3
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      “Hydroxychloroquine doesn’t have an RCT and remdesivir does!” Yes, true, and ALSO notice that hydroxychloroquine is a cheap generic so there’s nobody to *pay* for a big RCT.

      3 replies 4 retweets 36 likes
      Show this thread
    3. Sarah Constantin‏ @s_r_constantin May 3
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      And the public only knows about hydroxychloroquine because there’s this one doc with a bee in his bonnet about it (and he’s probably biased and sloppy and goes to the media too early and exaggerates.)

      2 replies 0 retweets 21 likes
      Show this thread
    4. Sarah Constantin‏ @s_r_constantin May 3
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      If it’s a cheap generic that *doesn’t* have a crazed fanboy, it’ll have even less apparent “success.” When was the last time you heard Discourse about indomethacin or niclosamide?

      1 reply 0 retweets 31 likes
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    5. Sarah Constantin‏ @s_r_constantin May 3
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      If you don’t like that the “standard of care” is biased towards the interests of a handful of pharma companies...maybe the problem is that you need to be a hundred-billion-dollar company to run a clinical trial that satisfies today’s FDA?

      1 reply 9 retweets 51 likes
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    6. Maximally‏ @maxefremov May 3
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      Replying to @s_r_constantin

      Is there any account of folks in positions of influence soberly realizing that the FDA can do more harm than good as a result of the pandemic?

      1 reply 0 retweets 3 likes
    7. Sarah Constantin‏ @s_r_constantin May 3
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      Replying to @maxefremov

      The FDA has loosened many of its usual restrictions because of the pandemic. The concept of risk-benefit tradeoffs is, I expect, very familiar to them. “Deregulation can ever be good” is clearly a notion the Trump administration has heard of.

      1 reply 0 retweets 4 likes
    8. Sarah Constantin‏ @s_r_constantin May 3
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      Replying to @s_r_constantin @maxefremov

      Actually deregulating to the extent I support would require what is commonly called “fanaticism” — willingness to keep pushing against resistance to the point of becoming a boor — which I think is selected against in all leadership positions, public or private.

      1 reply 1 retweet 19 likes
    9. Sarah Constantin‏ @s_r_constantin May 3
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      Replying to @s_r_constantin @maxefremov

      “I don’t care how nice, smart, or “reasonable” you are, I’m not gonna accept your excuses until the cost (or death rate, or w/e) goes down” is the attitude you need here.

      2 replies 2 retweets 17 likes
    10. Sarah Constantin‏ @s_r_constantin May 3
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      Replying to @s_r_constantin @maxefremov

      Because bureaucrats *are* nice, sincere, and extremely well educated. They will always have plausible reasons, which they actually believe, why some source of delay or cost is necessary. And, typically, you will get your explanation and feel sheepish and not push.

      1 reply 0 retweets 15 likes
      Sarah Constantin‏ @s_r_constantin May 3
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      Replying to @s_r_constantin @maxefremov

      (Trump is a boor but not a fanatic; he is willing to “disrespect” experts by pushing them on timelines and asking “stupid” but often essential questions, but he’s *not* monomaniacally focused on a single desired outcome, no matter the social cost.)

      9:16 AM - 3 May 2020
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      • WoodIsGood Emma 😷 Uh idk man Fork From Home acid shill sonya! supposedly? Joshua Skootsky 🍳 Kerry Ellard Nabeel Qureshi
      1 reply 0 retweets 10 likes
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        2. Sarah Constantin‏ @s_r_constantin May 3
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          Replying to @s_r_constantin @maxefremov

          Jeff Bezos is, by all accounts, a fanatic in this sense about cost-cutting within Amazon. I am not sure we have ever had a fanatic US President.

          1 reply 0 retweets 10 likes
        3. Sarah Constantin‏ @s_r_constantin May 3
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          Replying to @s_r_constantin @maxefremov

          A fanatic asks “ok but does it help with the Outcome?” every. single. time. to the point where if upending his own organization will help, he’ll do that. Larry Kramer was a fanatic. That’s why he got kicked out of the org he founded.

          1 reply 2 retweets 11 likes
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