Ok so here’s the news report (I couldn’t find a paper) showing Remdesivir improves time to recovery in #COVID19https://www.niaid.nih.gov/news-events/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19 …
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And here’s the Lancet study from China showing no mortality benefit from remdesivir:https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31022-9/fulltext?utm_campaign=tlcoronavirus20&utm_source=twitter&utm_medium=social …
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You’ll notice the NIH study...also doesn’t show a statistically significant mortality benefit for remdesivir!!
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As
@MarkHoofnagle pointed out, remdesivir is supposed to work via viral replication inhibition; it prevents RNA viruses from copying their genetic material.1 reply 0 retweets 12 likesShow this thread -
This means a trial on advanced
#COVID19 patients was never gonna tell us jack shit. Viral load in this disease peaks around the onset of symptoms!!3 replies 0 retweets 22 likesShow this thread -
Replying to @s_r_constantin
just because the peak load is then, doesn’t mean that lowering the viral load later won’t help.
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Replying to @babarganesh
You’re not testing your drug when you’d logically expect it to work best
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Replying to @s_r_constantin
There are probably a few reasons why a trial on recently infected people hasn’t been done. Easiest one to see is that you would need a much larger number of them given that most don’t have bad outcomes anyway. You couldn’t recruit in hospitals bc that’s too late
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you think people wouldn’t be willing to sign up in droves?
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Replying to @s_r_constantin
i dunno. maybe someone has already started planning this trial.
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