"divorce FiO2 from PEEP" -- at least in type L. this is a *different* ventilatory protocol than ARDSNet, because these aren't typical ARDS patients. If you don't have collapsed alveoli in the first place, extra pressure can cause barotrauma.
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does remdesivir work? that recent NEJM study is SUPER USELESS FOR ANSWERING THAT QUESTION. (ed: just what I thought!)
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but ok, 57% of remdesivir-treated patients that were intubated got to be extubated, which is a lot higher than typical base rates. but hey, no control group, we don't know what to make of this.
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"as many of you have noticed, we have many COVID-positive patients." god i love the gallows humor. Clinical trial recruitment should be a lot easier these days!
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should you treat COVID19 pneumonia with antibiotics? dr. laughs, who's gonna send a person with CT evidence of pneumonia home without antibiotics?!
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recent evidence says high-dose chloroquine causes cardiac issues & it isn't looking too effective either.
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do we want to be giving anti-IL6 receptor antibodies to deal with cytokine storms? like tocilizumab.
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retrospective uncontrolled Chinese studies are showing clinical & even mortality benefit from tocilizumab, but as usual, wait for the RCT before jumping to conclusions. (they're enrolling now!)
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should we be worried about giving people hardcore immunosuppressants when they have an infectious disease? well you do NOT want to be giving tocilizumab to anyone with mild disease where their immune system might fight it off.
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Replying to @s_r_constantin
yesterday’s TWiV they were talking about people getting fungal infections in their blood from the IL-1 inhibitors
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