i can have little a prior confirmation, as a treat: preprint examining cells found in bronchoalveolar lavage finds that in mild patients there are more CD8+ T cells, which are more clonally expanded, than in severe patients https://www.medrxiv.org/content/10.1101/2020.02.23.20026690v1.full.pdf …
that sounds like bad news for variolation, right? (it may not even be possible to get mild disease by giving low doses of virus?)
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yeah, to me it's quite murky. i've seen some evidence of a dose/response-ish relationship in formation of immune memory, e.g. if you don't have a high enough infectious dose then memory CD8+ T cells don't form (virus gets cleared too quickly). it seems plausible that...
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at some low-ish infectious dose you get "good enough" protection from reinfection/severe disease without taking 100% of the danger of a "typical" infectious dose. but can you cut mortality by 10x and still get "good enough" protection? i think i'd guess no
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