in one mouse paper, virally infected mice treated continuously with IL-6 produce ~80% less IgG than untreated mice 
ok, now I'm convinced; that's enough negative results that it's probably not a thing. (also we know there are asymptomatic people with high viral titers.)
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that sounds like bad news for variolation, right? (it may not even be possible to get mild disease by giving low doses of virus?)
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yeah, to me it's quite murky. i've seen some evidence of a dose/response-ish relationship in formation of immune memory, e.g. if you don't have a high enough infectious dose then memory CD8+ T cells don't form (virus gets cleared too quickly). it seems plausible that...
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