However, upon reinfection, memory B cells and Tfh cells are ready to go from early on. Antibodies are produced much earlier. But this is actually pathogenic. Why? Probably something to do with IgG antibodies getting into the lungs and activating macrophages via FcR
devil's advocate: could this just be a function of higher viral load causing higher antibody titers (and we know higher viral load -> more severe disease)?
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yes, definitely possible and probably happening in some cases, I’d guess. Buuut from what I’ve seen it isn’t actually clear that the trajectory of measured viral load differs much at all between severe and non-severe cases... [citation pending]
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