This is intriguing but I don't *completely* endorse prioritizing this over other clinical trials. My big question is how does this NET mechanism compare in importance to other cellular causes of ARDS and DIC? Does blocking it *completely* prevent these conditions? etc.
Ah that's interesting, thanks! Seems like an easy way to improve the method is to check in vitro for a donor whose serum neutralizes the virus? If the "active ingredient" isn't a specific antibody but some other circulating immune factors, selecting on antibody could be bad.
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in the small convalescent plasma studies of COVID released so far, they do look at neutralizing titers, but the funny thing is that the patients they’re treating ALREADY had high neutralizing titers (and in one of two cases, low to absent viral load)
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I wish someone would test convalescent snot! or some realistic version thereof. There was a group working on inhaled nebulized antibodies a year ago...
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