New post: Treating COVID-19 with dornase alfa to cut neutrophil extracellular trapshttps://the-lagrangian.github.io/2020/04/11/treating-covid-19.html …
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why a no brainer? failed RCTs in influenza, some hints antibodies are harmful in some cases of COVID-19, mechanism murky (what fractions of infused antibodies can even make it into lungs/respiratory tract? I’ve seen 1 in 2000 for RSV)...
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success in SARS and "it just makes sense" mostly, but yeah, those are good points.
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agreed on all counts. I think it's worth trying because I don't foresee a shortage of candidates to sign up for trials and because there are so few no-brainers
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as far as the significance in ARDS- it would have been great if the TRAUMADORNASE study linked had started a year or two ago!
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