New post: Treating COVID-19 with dornase alfa to cut neutrophil extracellular trapshttps://the-lagrangian.github.io/2020/04/11/treating-covid-19.html …
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The only treatment candidate I've seen that's *truly* a no-brainer is convalescent serum. I wish there were more but I'm struggling to find any that seem like they aren't subject to the usual low base rate of drug success in the clinic.
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why a no brainer? failed RCTs in influenza, some hints antibodies are harmful in some cases of COVID-19, mechanism murky (what fractions of infused antibodies can even make it into lungs/respiratory tract? I’ve seen 1 in 2000 for RSV)...
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