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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Sarah Constantin‏ @s_r_constantin Mar 31
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      https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v1.full.pdf … Hydroxychloroquine looks effective in the first randomized controlled trial!

      10 replies 67 retweets 292 likes
      Show this thread
      Sarah Constantin‏ @s_r_constantin Mar 31
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      The improvement is in symptoms and CT appearance of pneumonia; the study didn't measure viral titer. So I still have questions about *how* it works.

      12:09 PM - 31 Mar 2020
      • 15 Likes
      • Carlos MD. 𝕄 𝕀 𝕃 ℍ 𝔸 𝕌 𝕊 @micahstubbs Sven Varkel Leon T Adele Dewey-Lopez Ash Ciarán Fork From Home
      8 replies 0 retweets 15 likes
        1. David Chapman‏ @Meaningness Mar 31
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          Replying to @s_r_constantin

          David Chapman Retweeted Derek Lowe

          Icymihttps://twitter.com/Dereklowe/status/1245063478362214400 …

          David Chapman added,

          Derek LoweVerified account @Dereklowe
          We have some more hydroxychloroquine clinical data, so let's take stock of where we are so far: https://blogs.sciencemag.org/pipeline/archives/2020/03/31/comparing-chloroquine-trials …
          0 replies 0 retweets 2 likes
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        1. Vishal Gulati  😷‏ @vishalgulati_ Mar 31
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          Replying to @s_r_constantin

          Thanks for sharing. I think it is step in the right direction but I wish there was longer follow up. But I always say that 😬

          0 replies 0 retweets 1 like
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        1. mrgunn‏ @mrgunn Mar 31
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          Replying to @s_r_constantin

          mrgunn Retweeted Ethan Perlstein

          Some evidence on how it works here:https://twitter.com/eperlste/status/1245107006068805632?s=19 …

          mrgunn added,

          Ethan Perlstein @eperlste
          Lysosomotropism as a unifying antiviral #COVID19 mechanism: HCQ, chloroquine, azithromycin and ciprofloxacin are all cationic amphiphiles (CADs) with charged amines that accumulate in and alkalinize endolysosomal/ vesicular compartments, thereby inhibiting viral replication. https://twitter.com/biorxivpreprint/status/1245099137399508994 … pic.twitter.com/NNzJs1qjMg
          Show this thread
          0 replies 0 retweets 1 like
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        1. Stuart Buck‏ @stuartbuck1 Mar 31
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          Replying to @s_r_constantin

          Stuart Buck Retweeted Lucas Morin

          https://twitter.com/lucasmorin_eolc/status/1244954589931155456 …

          Stuart Buck added,

          Lucas Morin @lucasmorin_eolc
          A new randomized trial evaluating the efficacy of hydroxychloroquine has been posted yesterday on @medrxivpreprint. So, what's the deal here? [Thread] https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v1.full.pdf … 1/ pic.twitter.com/bhtqGuIZEi
          Show this thread
          0 replies 0 retweets 1 like
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        1. Gabe The Engineer‏ @gdbassett Mar 31
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          Replying to @s_r_constantin

          Gabe The Engineer Retweeted Yishan

          I found this discussion interesting, however I can't speak to it's accuracy: https://twitter.com/yishan/status/1244717172871409666 …

          Gabe The Engineer added,

          Yishan @yishan
          This paper appears to yield a number of VERY USEFUL hypotheses and treatment for critical patients if true: https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173 … (1/n) https://twitter.com/friedberg/status/1244098769206923264 …
          Show this thread
          0 replies 0 retweets 1 like
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        1. StCyrAnnie O  ⭐ ⭐ ⭐‏ @StcyrAnnie Apr 3
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          Replying to @s_r_constantin

          I found this video on how it works to be interesting.https://youtu.be/U7F1cnWup9M 

          0 replies 0 retweets 1 like
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        1. Bobby Lite‏ @BobbyLiteUp Mar 31
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          Replying to @s_r_constantin

          I believe it to be good news. I've yet to understand what type of patient would take this? Someone who is severely Ill or even mild cases? I've only heard of patients nearing death so I am just curious?

          0 replies 0 retweets 0 likes
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