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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Sarah Constantin‏ @s_r_constantin Mar 20
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      So, I was a bit wrong in my last post; upon looking at more studies it looks like non-invasive ventilation *does* reduce the risk of needing intubation.https://srconstantin.github.io/2020/03/20/non-invasive-ventilation.html …

      3 replies 3 retweets 27 likes
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    2. Sarah Constantin‏ @s_r_constantin Mar 20
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      This is good news for home CPAP-style COVID-19 devices; the chances look much better than I thought that, in a world where ICUs are unavailable, a non-invasive ventilation device could save your life.

      1 reply 0 retweets 11 likes
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    3. Sarah Constantin‏ @s_r_constantin Mar 20
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      It looks like non-invasive ventilation cuts the risk of intubation in half, relative to standard oxygen therapy, if you look at all adult cases of acute respiratory distress (which includes things like COPD, pulmonary edema, pneumonia.)

      2 replies 0 retweets 11 likes
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      Sarah Constantin‏ @s_r_constantin Mar 20
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      NIV is still going to aerosolize the virus, so it's still dangerous to do in hospitals or any public setting, but it might be valuable at home for people who are already self-quarantining, in the event that we run out of ICU space.

      9:54 PM - 20 Mar 2020
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      • Alex Boland 👑Neoliberal Reply Princess👑 Jprwg Pedro Ivan Lopez Natália Mendonça selentelechia Evan Ward
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        2. Sarah Constantin‏ @s_r_constantin Mar 20
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          if the hospitals are *not* overrun, your best bet if you can't breathe is to go to a hospital; they are better prepared to deal with the worst-case scenarios than anything you could rig up at home.

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        3. Sarah Constantin‏ @s_r_constantin Mar 20
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          But it looks like the US and many other countries are on track to run out of ICU space. So "plan B" measures are relevant.

          1 reply 0 retweets 5 likes
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        4. Sarah Constantin‏ @s_r_constantin Mar 21
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          There are considerations that make home NIV for COVID19 look worse than hospital NIV for all respiratory failure. COVID19 causes worse ARDS and more patients (40%) need intubation. Also we’d expect home care & rapidly prototyped devices to be worse than hospital care & devices.

          2 replies 0 retweets 1 like
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        5. Sarah Constantin‏ @s_r_constantin Mar 21
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          However 50% reduction in intubation rate has a lot of wiggle room to get worse before it’s “basically no benefit” relative to *nothing*. The point of comparison is “hospitals full, no treatment, die at home.”

          1 reply 0 retweets 3 likes
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        6. End of conversation
        1. Sarah Constantin‏ @s_r_constantin Mar 21
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          I’ve heard the concern that even at home, if you’re in an apartment building, aerosolizing the virus could infect your neighbors. Not sure what I think of this; facially it seems like a worry, but I don’t know how far the virus gets spread in practice.

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        1. Andrew Wheeler‏ @sixfootbrit Mar 21
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          Thanks for another confirmation data point. Much appreciated!

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