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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Jack Gallagher‏ @gallabytes Mar 14
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      Everyone talking about #makeventilators is missing the point. Yes, we're going to run out. No, it won't be pretty. But we don't have labor capacity to care for that many more than we can ventilate. We need O2 concentrators so that 2/3 of hospital cases can switch to home care.

      5 replies 5 retweets 34 likes
      Show this thread
    2. Sarah Constantin‏ @s_r_constantin Mar 15
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      Replying to @gallabytes

      Link to evidence that lots of people need oxygen concentrators but not ventilators?

      2 replies 0 retweets 16 likes
    3. Jack Gallagher‏ @gallabytes Mar 15
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      Replying to @s_r_constantin

      Chinese reports + American interviews of front line doctors collected by project open air https://drive.google.com/folderview?id=1D1_C_Bng3zqw2IDZmo3jYZDZDLNYm0tq … Interviewed doctors seem inconsistent about how much care those on oxygen need, but consistent that there's two scenarios: oxygen and intubation.

      2 replies 0 retweets 15 likes
    4. Sarah Constantin‏ @s_r_constantin Mar 15
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      Replying to @gallabytes

      That’s not the relevant consideration for whether *home* oxygen is useful for a large # of patients. In fact the interviews you linked are not consistent with that story.

      1 reply 0 retweets 5 likes
    5. Sarah Constantin‏ @s_r_constantin Mar 15
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      Replying to @s_r_constantin @gallabytes

      “When respiratory failure occurs it is FAST. It may be happening about 7-10 days from symptom onset, but very rapid from the time of hospital admission. Common scenario is: Admit the patient on 1 liter of oxygen by nasal canula (a very little bit.)”

      1 reply 1 retweet 5 likes
    6. Sarah Constantin‏ @s_r_constantin Mar 15
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      Replying to @s_r_constantin @gallabytes

      “Twelve hours later the patient needs more help with a device that pushes oxygenated air into their nose/mouth and down their airway into their lungs (NPPV, think like a CPAP machine). Twelve to 24 hours later they are intubated, on a ventilator, turned onto their bellies”

      1 reply 1 retweet 2 likes
    7. Sarah Constantin‏ @s_r_constantin Mar 15
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      Replying to @s_r_constantin @gallabytes

      In a scenario like this, there’s only a 12-hour window where a patient needs oxygen but doesn’t need ICU-level care. In which case, home availability of oxygen doesn’t free up that many medical resources.

      2 replies 1 retweet 7 likes
    8. Sarah Constantin‏ @s_r_constantin Mar 15
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      Replying to @s_r_constantin @gallabytes

      The world where home oxygen masks are still useful is one in which many patients a.) need oxygen, b.) will get *better* and not need hospitalization if they get oxygen; c.) will eventually need hospitalization if they get no early treatment.

      1 reply 0 retweets 3 likes
    9. Sarah Constantin‏ @s_r_constantin Mar 15
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      Replying to @s_r_constantin @gallabytes

      I still don’t know how common that scenario is. Ie how much better is oxygen treatment for mild pneumonia than no treatment?

      2 replies 0 retweets 2 likes
    10. Sarah Constantin‏ @s_r_constantin Mar 15
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      Replying to @s_r_constantin @gallabytes

      In a world where oxygen for mild pneumonia doesn’t prevent progression to ARDS, then home oxygen improves quality of life for mild cases but doesn’t take pressure off the medical system or prevent many deaths.

      2 replies 0 retweets 3 likes
      Sarah Constantin‏ @s_r_constantin Mar 15
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      Replying to @s_r_constantin @gallabytes

      important question: what NON-COVID19 diseases/conditions take up the most time & resources in hospitals? Are any of them easier to shift to “MVP” clinics than COVID19 itself?

      10:36 AM - 15 Mar 2020
      • 3 Retweets
      • 9 Likes
      • Spinning Cats Sarah McManus corvus frugilegus Karthik-wear-a-mask-Jagadeesan Uh idk man Timothy #masks4all Roy Ben Hoffman Henry Jack Gallagher
      1 reply 3 retweets 9 likes
        1. Henry‏ @TheAstralPirate Mar 15
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          Replying to @s_r_constantin @gallabytes

          This is a great question.

          0 replies 0 retweets 0 likes
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