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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Sarah Constantin‏ @s_r_constantin Mar 13
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      Mammoth Biosciences has developed a CRISPR-based COVID19 test, which can be conducted in 30 min, and is trying to expand to being available at the point of care. https://mammoth.bio/wp-content/uploads/2020/03/Mammoth-Biosciences-A-protocol-for-rapid-detection-of-SARS-CoV-2-using-CRISPR-diagnostics-DETECTR.pdf …

      3 replies 32 retweets 149 likes
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    2. Sarah Constantin‏ @s_r_constantin Mar 13
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      All of the reagents and devices necessary are listed in the link above and commercially available. The test is portable; you don't need a full lab to conduct it, just portable incubators, pipettes, and somewhere to keep reagents clean + cold.

      1 reply 5 retweets 22 likes
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    3. Sarah Constantin‏ @s_r_constantin Mar 13
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      This protocol assumes you already have extracted RNA from the sample. RNA extraction kits are in short supply: there is only one approved manufacturer (Qiagen) though a second (Roche) has recently been approved.https://www.the-scientist.com/news-opinion/rna-extraction-kits-for-covid-19-tests-are-in-short-supply-in-us-67250 …

      1 reply 2 retweets 13 likes
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    4. Sarah Constantin‏ @s_r_constantin Mar 13
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      Even to qualify for the FDA's Emergency Use Authorization requires validation of the entire testing workflow. As I understand, it would be illegal (?) to test patients without an EAU.https://www.modernhealthcare.com/technology/labs-face-challenges-creating-diagnosis-testing-covid-19 …

      1 reply 2 retweets 6 likes
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    5. Sarah Constantin‏ @s_r_constantin Mar 13
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      Sarah Constantin Retweeted Ian Quigley

      So while, as Ian tweeted earlier, you don't need an RNA test kit to do an RNA extraction (https://twitter.com/allmeasures/status/1238089400296202243 …) if you gave patients a COVID-19 test based on the "old-fashioned" phenol/chloroform RNA extraction method, that wouldn't be automatically approved.

      Sarah Constantin added,

      Ian Quigley @allmeasures
      This is truly the finest hour for anti-molecular-biology-kit cranks (I am also a member) https://twitter.com/biochem_bri/status/1238037558921179141 …
      Show this thread
      1 reply 1 retweet 6 likes
      Show this thread
      Sarah Constantin‏ @s_r_constantin Mar 13
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      I'm struggling to figure out what would happen, concretely, to a doctor who tested patients with unapproved tests, or a laboratory that provided them. (Fines? Loss of license? what are the penalties here?)

      2:58 PM - 13 Mar 2020
      • 23 Likes
      • Basil Marte Isaiah Nudrinfe Pamela J. Hobart Michael Keenan dust Dogs Don't Make Jokes Near Humorless People Seb Insua sonya! supposedly?
      5 replies 0 retweets 23 likes
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        2. Ben Reinhardt‏ @Ben_Reinhardt Mar 13
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          Replying to @s_r_constantin

          If the blocker is simply someone willing to take on risk I will volunteer to go to jail in order to test people. No joke.

          1 reply 0 retweets 4 likes
        3. Sarah Constantin‏ @s_r_constantin Mar 15
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          Replying to @Ben_Reinhardt

          That’s commendable, but not as useful as understanding what the enforcement landscape is like. If you test one person and go to jail immediately, you can’t help any more people. In a situation where medical personnel are already scarce, that’s bad.

          1 reply 0 retweets 3 likes
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        2. St. Rev  ☯️ 🏴 😻‏ @St_Rev Mar 14
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          Replying to @s_r_constantin

          This is exactly what happened to the Washington flu research group who found community spread back in February. FDA cease & desisted them.

          1 reply 1 retweet 9 likes
        3. Eddie in a Hazmat Suit‏ @random_eddie Mar 14
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          Replying to @St_Rev @s_r_constantin

          It shouldn't be a problem any longer, though. The FDA has granted blanket approval to any lab to develop and use their own tests. Any lab that already has the capability to do genetic testing routinely could start testing for CV19 within days. And many have.

          2 replies 0 retweets 0 likes
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        1. Invert Avian‏ @Invert_Avian Mar 13
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          Replying to @s_r_constantin

          Related q: would the same/equally-bad regulations apply to tests done for epidemiological purposes? If someone was running tests just towards knowing the infection stats (and hiding results from Dr.s/patients, perverse as that seems) would they face FDA/CDC retribution?

          0 replies 0 retweets 2 likes
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        1. Arnav Bansal‏ @itsarnavb Mar 13
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          Replying to @s_r_constantin

          If these became court cases, would they go through a jury?

          0 replies 0 retweets 0 likes
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        1. Scott Leibrand‏ @scottleibrand Mar 13
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          Replying to @s_r_constantin

          Scott Leibrand Retweeted Mike Baker

          Probably depends on what you did with the results. If you did it as research and didn’t use results to make any medical or public health decisions (except to make sure any positive results got tested with an approved test), you’d basically be doing this: https://twitter.com/bymikebaker/status/1237555003352469509?s=21 …https://twitter.com/ByMikeBaker/status/1237555003352469509 …

          Scott Leibrand added,

          Mike BakerVerified account @ByMikeBaker
          EXCLUSIVE: For weeks, thousands of flu samples sat in Seattle as researchers sought to test and flag them for coronavirus. The C.D.C. wouldn’t allow it. When testing did happen, it was too late. The virus was upon us. https://www.nytimes.com/2020/03/10/us/coronavirus-testing-delays.html … w/ @sherifink
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          0 replies 0 retweets 0 likes
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