https://www.frontiersin.org/articles/10.3389/fimmu.2018.00229/full … Interesting hypothesis for how CFS works. An infection causes an immune response; some of the antibodies produced attack mitochondria (which, after all, originated as bacteria) and make energy metabolism less efficient, causing fatigue.
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perhaps one part of the puzzle is that mitochondria sometimes exist outside cells:https://www.the-scientist.com/news-opinion/researchers-find-cell-free-mitochondria-floating-in-human-blood--67071 …
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huh, weird! My guess would have been that anti-mitochondria Abs are basically responding to dead/damaged cells/debris but may not do anything since they can’t reach intact mitochondria...but the whole notion of infections triggering autoimmunity is a big interesting one
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In medschool we memorize that Anti-mitochondrial antibodies are pathomnemonic for Primary Biliary Cholangitis. I wonder if that's oversimplified though and there are different mitochondrial antigens being represented in the anti-mito antibodies in various conditions
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