Had a call with the @jacksonlab Yesterday. They apparently:
A) View telomere elongation as simple mutations.
B) Are also not able to easily say which mouse lines may have had changes in breeding protocols.
C) Do not monitor telomere length.
according to their representative.https://twitter.com/jacksonlab/status/1232485456601698304 …
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Replying to @EricRWeinstein @jacksonlab
"A) View telomere elongation as simple mutations." Why is this so important when it comes to producing mass-bred mice? cc
@s_r_constantin3 replies 0 retweets 0 likes -
iirc short-telomere’d humans don’t age faster than long-telomere’d humans? Not sure telomere length is much use as a predictor.
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Replying to @s_r_constantin @InquilineKea and
Some evidence exists for Epitalon and related peptide activators of telomerase in reducing annual mortality among aged cohorts, but more work by researchers outside of Russia is needed.
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Replying to @__ice9 @s_r_constantin and
More generally, though, shorter telomeres are indeed associated with higher all-cause mortality. This is not particularly controversial across different studies by different researchers.https://www.sciencedirect.com/science/article/pii/S1568163718301235 …
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Replying to @__ice9 @InquilineKea and
Ok, I may have misremembered, thanks.
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Oh, it was in mice where telomere length wasn’t associated with lifespan: https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=telomere+length+and+lifespan+in+mice&btnG=#d=gs_qabs&u=%23p%3DFkCshe0CdwwJ …
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Replying to @s_r_constantin @InquilineKea and
Hmm yes-- this is also across different strains instead of being a proper RCT, but in general it does not appear that maximum lifespan itself is affected.
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