You know how hypothalamic function declines with age? This paper seems to isolate an essential mechanism for that, and shows that it can be reversed. (In mice, of course.)https://twitter.com/aginghighlights/status/1222965066850603009 …
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There's a particular noncoding RNA that is found in the hypothalamus and declines sharply with age. Knock it out and you get shorter-lived, faster-aging mice with more senescence and fewer stem cells in the hypothalamus.
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How does this non-coding RNA (Hncsr) work? It binds a protein called YB-1, protecting it from degradation, and this protein inhibits the expression of the senescence marker p16. Not enough Hncsr and you impair the animal's ability to block senescence.
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A natural product found in black tea, Theaflavin 3-Gallate, was predicted by a virtual screen of molecules to mimic Hncsr's ability to protect YB-1, and indeed, administering it to middle-aged mice prevented hypothalamic stem cell senescence.
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Replying to @s_r_constantin
Good news it's in black tea, bad news: if one wants pure stuff, it costs 230 bucks for 10mg as of now. :( (The preview of the article doesn't say how much was administered to mice. So maybe 10mg is plenty?)
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Replying to @xtremalraven
I wouldn’t get that excited about taking it just yet tbh. They did do some safety testing on the mice here, but if it were me I’d wait for at least a replication and/or a test in larger animals, if not a test on human subjects.
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Replying to @s_r_constantin
Oh. Right… Ok, we'll wait, I guess. The way they discovered it is also pretty cool!
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Yeah! I haven’t seen that many examples of in silico structure prediction working. I can’t access the supplementary material — can you find details anywhere?
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Replying to @s_r_constantin
No, can't find details as well. But seems like Elsevier wants just 10 bucks for renting it for a day…
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