You know how hypothalamic function declines with age? This paper seems to isolate an essential mechanism for that, and shows that it can be reversed. (In mice, of course.)https://twitter.com/aginghighlights/status/1222965066850603009 …
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Replying to @s_r_constantin
You know how people make graphs of the expected lifespan of humans over time? Like we tend to live a couple of years longer this century than we did last century and so on. I'd like to see that for lab mice.
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Replying to @zooko @s_r_constantin
José Luis Ricón Fernández de la Puente Retweeted José Luis Ricón Fernández de la Puente
Ask and thou shalt receive (Thread I did https://twitter.com/ArtirKel/status/1188522622998450176 … )
José Luis Ricón Fernández de la Puente added,
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My question is David Brin's, how likely is it that all these settings are mostly already on in humans? We do have a crazy high number of lifetime heartbeats.
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It's likely! I think we should be studying interventions on animals that are longer lived for their size than mice. (Porcupines & squirrels, for instance.)
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OTOH we know that humans don't have *all* the long-life switches turned on, because there are animals that live longer than us (some tortoises & whales) and animals that don't get cancer (elephants) or senescence at all (naked mole rats).
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Or even our senescent cells could be more nicely behaved (like in Spalax, a naked mole rat cousin that seems to have a very mild SASP)
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