You know how hypothalamic function declines with age? This paper seems to isolate an essential mechanism for that, and shows that it can be reversed. (In mice, of course.)https://twitter.com/aginghighlights/status/1222965066850603009 …
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The treated mice, after 6 months, also showed reduced age-related cognitive and motor deficits, better insulin sensitivity, and higher bone mass. The study didn't follow them long enough to test the effect on lifespan.
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Of course, this doesn't prove that this is the *only* mechanism causing hypothalamic stem cell decline or aging symptoms downstream of it. But it does show that this is *a* causal mechanism.
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Good news it's in black tea, bad news: if one wants pure stuff, it costs 230 bucks for 10mg as of now. :( (The preview of the article doesn't say how much was administered to mice. So maybe 10mg is plenty?)
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I wouldn’t get that excited about taking it just yet tbh. They did do some safety testing on the mice here, but if it were me I’d wait for at least a replication and/or a test in larger animals, if not a test on human subjects.
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