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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging. Founder, LRI and Daphnia Labs. Discourse goes here.

Be
srconstantin.wordpress.com
Joined February 2019

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    Sarah Constantin‏ @s_r_constantin Jan 30
    • Report Tweet

    Sarah Constantin Retweeted Aging Highlights

    You know how hypothalamic function declines with age? This paper seems to isolate an essential mechanism for that, and shows that it can be reversed. (In mice, of course.)https://twitter.com/aginghighlights/status/1222965066850603009 …

    Sarah Constantin added,

    Aging Highlights @aginghighlights
    Reducing Hypothalamic Stem Cell #senescence protects against aging-associated physiological decline in mice https://www.sciencedirect.com/science/article/abs/pii/S1550413120300024 …
    11:49 AM - 30 Jan 2020
    • 7 Retweets
    • 16 Likes
    • Dr Cosmo halvorz Mark (🧘🧪🧙‍♂️💩❤️) Raj Balakrishnan Jaime Sevilla Aging Highlights Valence Smith XAR 🦉 Dr. Mike Lustgarten
    2 replies 7 retweets 16 likes
      1. New conversation
      2. Sarah Constantin‏ @s_r_constantin Jan 30
        • Report Tweet

        There's a particular noncoding RNA that is found in the hypothalamus and declines sharply with age. Knock it out and you get shorter-lived, faster-aging mice with more senescence and fewer stem cells in the hypothalamus.

        1 reply 0 retweets 5 likes
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      3. Sarah Constantin‏ @s_r_constantin Jan 30
        • Report Tweet

        How does this non-coding RNA (Hncsr) work? It binds a protein called YB-1, protecting it from degradation, and this protein inhibits the expression of the senescence marker p16. Not enough Hncsr and you impair the animal's ability to block senescence.

        1 reply 0 retweets 2 likes
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      4. Sarah Constantin‏ @s_r_constantin Jan 30
        • Report Tweet

        A natural product found in black tea, Theaflavin 3-Gallate, was predicted by a virtual screen of molecules to mimic Hncsr's ability to protect YB-1, and indeed, administering it to middle-aged mice prevented hypothalamic stem cell senescence.

        2 replies 0 retweets 3 likes
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      5. Sarah Constantin‏ @s_r_constantin Jan 30
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        The treated mice, after 6 months, also showed reduced age-related cognitive and motor deficits, better insulin sensitivity, and higher bone mass. The study didn't follow them long enough to test the effect on lifespan.

        1 reply 0 retweets 3 likes
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      6. Sarah Constantin‏ @s_r_constantin Jan 30
        • Report Tweet

        Of course, this doesn't prove that this is the *only* mechanism causing hypothalamic stem cell decline or aging symptoms downstream of it. But it does show that this is *a* causal mechanism.

        1 reply 0 retweets 1 like
        Show this thread
      7. End of conversation
      1. New conversation
      2. zooko‏ @zooko Jan 30
        • Report Tweet
        Replying to @s_r_constantin

        You know how people make graphs of the expected lifespan of humans over time? Like we tend to live a couple of years longer this century than we did last century and so on. I'd like to see that for lab mice.

        1 reply 1 retweet 2 likes
      3. José Luis Ricón (Artir)‏ @ArtirKel Jan 30
        • Report Tweet
        Replying to @zooko @s_r_constantin

        José Luis Ricón (Artir) Retweeted José Luis Ricón (Artir)

        Ask and thou shalt receive (Thread I did https://twitter.com/ArtirKel/status/1188522622998450176 … )

        José Luis Ricón (Artir) added,

        José Luis Ricón (Artir) @ArtirKel
        Progress in making MICE! live longer This is looking at median lifespan, not max lifespan, not looking at sample sizes and robustness of effects just yet. pic.twitter.com/LMSGSZcuxX
        Show this thread
        3 replies 1 retweet 1 like
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