It's the interplay between cost of doing studies in mammals and invertebrates, how conserved the targets are across species. So it can be that it's cheaper to skip inv. studies if they almost never translate. Conversely, for some p, using inv. to screen is better
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I haven’t found enough published studies to even get an estimate of translatability, except in antibiotics, where it’s quite good.
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Missing/extra steps/paths in the molecular circuitry. Even if the node you're interested in tinkering with does exist in this network, it may have more/fewer and critically different nearby nodes. It's almost absurd on its face to attempt.
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The drug is already approved for a different indication (no need to inv tox studies)
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