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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Sarah Constantin‏ @s_r_constantin Jan 13
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      https://www.statnews.com/2020/01/12/venture-capitalist-alexis-borisy-bring-down-drug-prices/ … Does anybody understand why this business model hasn't been done before? (Develop new drugs that mimic the effects of other approved drugs; sell them at lower prices; make a profit by gaining market share.)

      4 replies 0 retweets 9 likes
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    2. halvorz ¯\_(ツ)_/¯‏ @halvorz Jan 13
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      Replying to @s_r_constantin

      they're betting on less risk because they're following known development paths but I'm not confident this actually lowers risk enough

      1 reply 0 retweets 1 like
    3. halvorz ¯\_(ツ)_/¯‏ @halvorz Jan 13
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      Replying to @halvorz @s_r_constantin

      it could! but there are plenty of examples of me-too drugs that are surprisingly different in efficacy/side effects, and those sometimes don't show up until you've blown a bunch of money on phase 3 trials

      1 reply 0 retweets 3 likes
    4. halvorz ¯\_(ツ)_/¯‏ @halvorz Jan 13
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      Replying to @halvorz @s_r_constantin

      otoh hep-c drugs might be an example of how this could work in practice gilead was raking in the cash at first w sovaldi but it seems like competition has actually put some pricing pressure on them

      2 replies 0 retweets 1 like
      Sarah Constantin‏ @s_r_constantin Jan 13
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      Replying to @halvorz

      Ok, that's an argument for caution that makes sense -- that me-too drugs are actually difficult to produce cheaply. I *don't* get why the article seems to imply that even *if* you had a cheaper me-too drug, that payors might not switch to it.

      2:08 PM - 13 Jan 2020
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        1. halvorz ¯\_(ツ)_/¯‏ @halvorz Jan 13
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          Replying to @s_r_constantin

          same reason profs keep making their students pay out the nose for new textbooks

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