We don’t know what signals menopause to happen! We don’t know why it’s so incredibly variable (it can last anywhere from two to ten years, and happen anywhere from your thirties to your fifties.)
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You can do all kinds of freaky things by stimulating different parts of the hypothalamus: make a mouse drink, make it lose or gain weight, alter sexual activity, etc.
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And of course a lot of these hypothalamic responses get disrupted with age, and you can delay aging by manipulating the hypothalamus (eg heating it makes mice live longer!)
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so similar methods are probably usable to understand how female reproductive function is regulated and changes with age (albeit not true menopause; you're not going to get to drill holes in healthy women's skulls For Science.)
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