https://www.statnews.com/2019/12/10/large-pharma-companies-provide-little-new-drug-development-innovation/ … 81% of Pfizer's and J&J's new drugs were discovered by third parties. Pharma companies mostly don't do their own discovery; they partner with and acquire smaller biotech companies.
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What it means is that preclinical-stage biotech startups are mostly not competing with Big Pharma so much as selling to Big Pharma. The best early-stage R&D happens outside the big companies, and pharma execs *know this*.
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This is not news to people in biotech but I keep seeing people outside the industry get confused about it. “How will a brand new startup ever be able to afford to bring a drug to market?” They don’t! They partner with bigger companies. Or license IP, or get acquired.
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There’s something to be said for being expert manufacturers who know how to scale
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I'm also confused by the idea that drug prices should compensate for "research", but not for "development", which Pfizer, etc do a lot of. If development is a significant cost driver, and without it we wouldn't have the drugs, then yes, prices should compensate for that too.
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Not to mention a lot of these biotechs get plenty of funding though investment arms of these same firms. These deals get done often due to pre-existing relationships.
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