Possible irrationality in biomedical research: small-N human studies get derided as “too small, preliminary” even if the effect is clear and consistent enough to have a low p-value; animal studies often use tiny numbers of animals or don’t even list the number.
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RhoGam was discovered from the blood of a single patient.
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PCSK9 inhibitors from both gain and loss of functions in small natural human populations.
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