I’m going through a bunch of comparative transcriptomics & genomics papers purporting to find genes associated with aging by looking at either which genes are overexpressed in young vs old animals, or highly mutated between long-lived vs short-lived species.
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why $200K? Our housing cost is about $0.1/mouse/day in shared cages, so (rounding up) about $5K/yr for 100 mice. So if a mouse lives 4 yrs then that's $20K for 100 mice.
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knocking out 20K genes 1 at a time would still be a lot: $400M. And would likely not reveal much because of gene interactions and dosage effects.
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How much of that is salary and could be reduced by offshoring?
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