I’m going through a bunch of comparative transcriptomics & genomics papers purporting to find genes associated with aging by looking at either which genes are overexpressed in young vs old animals, or highly mutated between long-lived vs short-lived species.
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Oh yeah good point. I guess you could do it in two passes - group test to find the fatal ones then on the remaining non fatal ones to see which ones help - but it makes the idea a lot less appealing
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this is yeast, but it seems like deleting any set of three genes is almost guaranteed to be bad. this makes the existence of clusters you can knock out very interestinghttps://www.quantamagazine.org/how-many-genes-do-cells-need-maybe-almost-all-of-them-20180419/ …
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