I’m going through a bunch of comparative transcriptomics & genomics papers purporting to find genes associated with aging by looking at either which genes are overexpressed in young vs old animals, or highly mutated between long-lived vs short-lived species.
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There’s almost no intersection between papers so far — even the ones that refer to the same tissue type in the same species. Am I missing something, or is this fairly damning to the hypothesis “correlational signatures of aging & longevity make good drug targets”?
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Replying to @s_r_constantin
Check out the meta-analysis out of Church's lab ... kinda old though :https://academic.oup.com/bioinformatics/article/25/7/875/210443 …
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Replying to @subC0smos
Yeah a ton has been done since then, but that’s cool! I didn’t know there was a unified database!
6:31 AM - 8 Dec 2019
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