The lysosomal storage disorder Neimann-Pick Disease is caused by mutations in the transporters that remove cholesterol from the lysosomes. Lysosomal cholesterol is the signal for mTORC1, so this disorder may progress via the aberrant growth phenotype of stimulating mTORC1. #BAAM
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NPC-diseased cells have less autophagy and more fragmented mitochondria; Torin1 fixes it.
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