The “blood-brain barrier” isn’t; even in healthy brains it lets through plasma proteins. With age, there seems to be a shift from receptor-mediated transport to nonspecific caveolar transport. Cool talk from Andrew Yang of the Wyss-Corey Lab! #BAAM
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This should give us pause whenever we assume that some compound or drug “can’t cross the blood-brain barrier.” The permeability of the BBB changes with age & is regulated by the expression of cell surface receptors & active transport-related genes.
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