IDO1 knockout mice are also resistant to diet-induced obesity; kynurenine affects metabolic disease too!https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851598/ …
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So if you have a *chronic* viral infection, you’re going to keep pumping out kynurenines as a side effect of trying to kill the virus, which cause immunosuppression, which makes you more susceptible to viral infection...it’s a vicious cycle!
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What kinds of drugs inhibit IDO and TDO? Well, azole antifungals (like ketoconazole) and the MAOI antifungal phenelzine (also known as Nardil, the Flame of the West) https://scholar.google.com/scholar?start=20&q=ido1+inhibitor&hl=en&as_sdt=0,5#d=gs_qabs&u=%23p%3DYbQyk8FoSIMJ …
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The antiviral acyclovir is also an IDO1 inhibitor:https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-7-44 …
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Acyclovir inhibits TDO too:https://link.springer.com/article/10.1007%2Fs11011-008-9095-4 …
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And so does the antibiotic minocycline:https://www.sciencedirect.com/science/article/abs/pii/S1043466617303848 …
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