http://jpet.aspetjournals.org/content/jpet/371/1/1.full.pdf … This is big news; an antipsychotic that's NOT a D2 agonist.
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Antipsychotic drugs do block hallucinations, but they also have scary side effects: they cause motor disorders, cognitive impairment, and the newer ones cause extreme weight gain.https://srconstantin.wordpress.com/2017/05/25/antipsychotics-might-cause-cognitive-impairment/comment-page-1/#comment-21557 …
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Blocking D2 causes motor disorders and cognitive impairment; blocking 5HT2A causes sedation and weight gain. This new drug does neither.
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https://academic.oup.com/schizophreniabulletin/article/45/Supplement_2/S199/5434347 … Other antipsychotics don't do anything for the negative symptoms of schizophrenia (the cognitive impairment and loss of motivation.) This one does: 0.48 effect size on negative symptoms in an RCT!
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What's cool is that it was discovered phenotypically; researchers put mice in "SmartCube" boxes where their behavior was monitored on video through a variety of tests. This allows drugs to be clustered (as anxiolytics, stimulants, etc) based on their effects on behavior.
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Replying to @s_r_constantin
Do you know how they select drugs to test in the SmartCube?
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Replying to @louislva
They started with a standard library of psychoactive drugs to validate/calibrate the platform, and then they partnered with pharma companies to screen their libraries.
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Replying to @s_r_constantin
So they try many drugs on mice in the SmartCube, to see if a small % of them match? Thinking it must be hard to screen discover drugs with novel mechanisms of action.
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Replying to @louislva
Yes. I think they must have some intelligent preselection process or else it would be hugely inefficient.
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Replying to @s_r_constantin
How do you do it at Daphnia? Automated? Someone picks out molecules? I find this very interesting!
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We can do larger libraries since we’re using invertebrates not mice.
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