There are tons of rodent studies showing that various compounds have “neuroprotective” effects: that is, if you damage the brain by hypoxia or blunt force trauma, the animal’s cognitive function recovers better if you administer a drug right after injury.
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I think timing is the most likely factor you suggest. Same thing in cancer models where they administer the drug at the same time they implant the tumor. It’s a preventative model in disguise.
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Human brains are abnormal by mammal standards. They're huge and may already have a lot of physical trauma due to size and momentum and be well adapted for it where rat brains are small and not adjusted for such things
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