These studies basically never translate to humans. Casually it seems like an unusually bad translation rate, compared to drugs in general. Anyone know why?
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Guesses: a.) brains are hard; b.) most human TBI patients are old, whereas mouse models of TBI aren’t; c.) in real life people don’t get treated *immediately* after a head injury or stroke, whereas lab mice with experimentally-induced injuries are
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Do you have a particular human trial in mind?
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