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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Sarah Constantin‏ @s_r_constantin 2 Oct 2019
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      The natural comparison to uBiome is Theranos, because that’s another female-founded health-tech fraud. But the types of fraud are actually very different.

      1 reply 0 retweets 1 like
      Show this thread
    2. Sarah Constantin‏ @s_r_constantin 2 Oct 2019
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      Theranos’s tech would have been unquestionably valuable (to patients, drugstores, insurers, etc) had it worked. And something like it probably could have worked. It just didn’t. Elizabeth Holmes lied to everyone about the tech, and went to extreme lengths to avoid discovery.

      2 replies 0 retweets 4 likes
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    3. Roko Mijic‏ @RokoMijicUK 2 Oct 2019
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      Replying to @s_r_constantin

      I get the impression that Theranos' tech could work for some applications if it was competently executed. There must be a huge amount of useful information in a capillary blood sample, and probably there is some level of tech that could extract it. Yes?

      1 reply 0 retweets 1 like
    4. Sarah Constantin‏ @s_r_constantin 2 Oct 2019
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      Replying to @RokoMijicUK

      That’s what I thought but apparently @halvorz disagrees.

      2 replies 0 retweets 2 likes
    5. halvorz ¯\_(ツ)_/¯‏ @halvorz 2 Oct 2019
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      Replying to @s_r_constantin @RokoMijicUK

      my understanding (to be clear this is not my area of expertise) is that the tiny volumes of blood used inevitably lead to wildly variable results, especially if you want to run multiple tests from a single draw

      3 replies 0 retweets 0 likes
    6. Roko Mijic‏ @RokoMijicUK 2 Oct 2019
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      Replying to @halvorz @s_r_constantin

      I doubt that there's literally no info in that blood. Maybe one needs to rethink all the tests. Instead of testing one compound, make a model that predicts things using all the available info and a big, sophisticated ML model. BTW, would I look good in a black turtleneck?

      2 replies 0 retweets 2 likes
    7. Sarah Constantin‏ @s_r_constantin 2 Oct 2019
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      Replying to @RokoMijicUK @halvorz

      You need a biobank or hospital partnership to make that happen, but maybe!

      1 reply 0 retweets 1 like
    8. Sarah Constantin‏ @s_r_constantin 2 Oct 2019
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      Replying to @s_r_constantin @RokoMijicUK @halvorz

      But then you run into the same problem as uBiome. If you’re not measuring the levels of a specific molecule, but your own composite score, then you have to prove to the satisfaction of doctors and insurers that this score can be used to make actual medical decisions.

      2 replies 0 retweets 0 likes
    9. Roko Mijic‏ @RokoMijicUK 2 Oct 2019
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      Replying to @s_r_constantin @halvorz

      I don't have a good intuition for how hard the regulatory hurdle is. But it's obvious to me that a composite score will outperform [M] for any single molecule M.

      1 reply 0 retweets 0 likes
    10. halvorz ¯\_(ツ)_/¯‏ @halvorz 2 Oct 2019
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      Replying to @RokoMijicUK @s_r_constantin

      a composite score for what?

      2 replies 0 retweets 0 likes
      Sarah Constantin‏ @s_r_constantin 2 Oct 2019
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      Replying to @halvorz @RokoMijicUK

      It might! But it isn’t in use *yet* and you have to convince doctors that it’s better than what they’re doing, and they’ll want human data, and they probably should.

      8:35 AM - 2 Oct 2019
      1 reply 0 retweets 0 likes
        1. New conversation
        2. Sarah Constantin‏ @s_r_constantin 2 Oct 2019
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          Replying to @s_r_constantin @halvorz @RokoMijicUK

          So unless you can go back in time and teach doctors from the 1950s or before about machine learning, you have to run human studies.

          2 replies 0 retweets 0 likes
        3. Sarah Constantin‏ @s_r_constantin 2 Oct 2019
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          Replying to @s_r_constantin @halvorz @RokoMijicUK

          “Make human studies cheaper” is a great deregulation mission. “We don’t need no stinkin’ human studies” is a terrible one. (It figures that the latter is what has gotten political traction.)

          0 replies 0 retweets 1 like
        4. End of conversation

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