Derek Lowe is a voice of conservatism in drug development so it means something when he says that you don't strictly speaking need to know the protein target to get a drug to market. What the FDA cares about, correctly, is safety and efficacy, in mammals and then humans.https://twitter.com/Dereklowe/status/1176852451577741312 …
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Replying to @s_r_constantin
does anybody actually involved in drug development dispute this? plenty of examples of drugs that we don't really know the mechanism of action
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Replying to @halvorz
I do sometimes hear industry people get spooked if you say you aren't *starting* with a proposed mechanism...despite the fact that lots of the mechanisms we thought we knew, we actually were wrong about.
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Replying to @s_r_constantin @halvorz
counterpoint is that the small molecules that passes whatever phenotype screen is not the exact thing entering the clinical. Chemists can derivatize to optimize but the search space is still huge: structure and MOA can narrow it.
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I agree.
7:33 AM - 26 Sep 2019
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