Derek Lowe is a voice of conservatism in drug development so it means something when he says that you don't strictly speaking need to know the protein target to get a drug to market. What the FDA cares about, correctly, is safety and efficacy, in mammals and then humans.https://twitter.com/Dereklowe/status/1176852451577741312 …
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counterpoint is that the small molecules that passes whatever phenotype screen is not the exact thing entering the clinical. Chemists can derivatize to optimize but the search space is still huge: structure and MOA can narrow it.
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I agree.
End of conversation
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It's almost as if it's more important to sound like you know what you're talking about than to actually know what you're talking about.
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