You know those startups that sound like they're tackling a big problem (like "healthcare" or "climate change") but the thing they plan to build can only fix a tiny part of the problem, even if they executed it perfectly?
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My other opinion is that an ecosystem of small-ish firms each making an incremental contribution is more likely to work the more functional the background institutions of society are. E.g. the Industrial Revolution was a lot of little inventions, not one Tony Stark's grand plan.
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If you don't have adequate coordination between firms, e.g. in broken markets, then you're more likely to see success with bigger firms that integrate a lot "under one roof".
End of conversation
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