Test. Things. On. Patients. See if the patients get well. Not a biomarker. Not a surrogate endpoint. See if they get well. Because you might be *wrong* about how you think the disease works. Oh, RCT's are expensive? Maybe let patients fund them! Maybe loosen IRB requirements! https://twitter.com/VPrasadMDMPH/status/1172287910680248320 …
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You could certainly set up an RCT for that. It wouldn’t be double-blinded, as behavior interventions can’t be, but people’s instructions can be randomized, and you can have them track their diets to observe who actually follows the instructions.
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