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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Sarah Constantin‏ @s_r_constantin 25 Aug 2019
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      I'm reading The House of God and it's pretty much exactly the Lewis Thomas contrarian take on medicine.

      2 replies 1 retweet 14 likes
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    2. Sarah Constantin‏ @s_r_constantin 25 Aug 2019
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      Lots of modern medicine doesn't actually work; the stuff that does work (like vaccines) is cheap and doctors will spend little time on it; most doctor time and medical cost is spent on managing chronic diseases of aging that we cannot cure.

      2 replies 0 retweets 16 likes
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    3. Sarah Constantin‏ @s_r_constantin 25 Aug 2019
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      Caring for the chronically/permanently ill is still important but it's depressing as hell and often more about kindness and low-tech caretaking than "cure."

      1 reply 0 retweets 7 likes
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    4. Sarah Constantin‏ @s_r_constantin 25 Aug 2019
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      You could read this in a fatalist sense — “we need to accept illness and death as a reality and be kind to each other instead of obsessing over fancy medical technologies” — but that’s not my takeaway.

      1 reply 0 retweets 2 likes
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    5. Sarah Constantin‏ @s_r_constantin 25 Aug 2019
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      My takeaway is that, once you admit that current medicine really can’t help a lot of people, that’s a really strong argument for inventing medicine that can.

      2 replies 3 retweets 24 likes
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    6. Roko Mijic‏ @RokoMijicUK 25 Aug 2019
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      Replying to @s_r_constantin

      I'm interested to know how responsive to effort the problem of stopping aging is. If we could add just 30 or so years to healthspan, there would almost certainly be a social recognition that the problem is solvable and huge extra money would flow in. But a model ..

      1 reply 0 retweets 2 likes
    7. Roko Mijic‏ @RokoMijicUK 25 Aug 2019
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      Replying to @RokoMijicUK @s_r_constantin

      .. I have in my mind is that the problem might go from impossible to easy at some point in the future based on other tech, so actually aging is almost completely unresponsive to any currently feasible amount of effort. ???

      1 reply 0 retweets 0 likes
    8. Sarah Constantin‏ @s_r_constantin 25 Aug 2019
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      Replying to @RokoMijicUK

      I think it’s probably easy, it’s just hugely under-researched.

      1 reply 0 retweets 1 like
    9. Roko Mijic‏ @RokoMijicUK 25 Aug 2019
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      Replying to @s_r_constantin

      this is in the top 2 most important questions in the world. What makes you think it's easy now? We know enough now to say almost for certain that the cost of a 30 year healthspan extension (i.e. 50=20, 80=50) any time before, say 1980 was ∞

      1 reply 0 retweets 0 likes
      Sarah Constantin‏ @s_r_constantin 25 Aug 2019
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      Replying to @RokoMijicUK

      Obvious “overview” experiments (drug screens for life extension in animals) are rarely done and when they are done they show abundant positive results. 30% life extension in mice has been achieved by multiple methods. “Omics” longitudinal & comparative studies of aging are new.

      11:07 AM - 25 Aug 2019
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      • Biswapriya Misra Alexander Kruel John Greer Roko Mijic
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        2. Roko Mijic‏ @RokoMijicUK 25 Aug 2019
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          Replying to @s_r_constantin

          30% life extension for a simple drug has a "too good to be true" feel to it, though obviously hard for me to be sure as a non-biologist Somebody found a sophisticated way to poison mice or give them some deficiency and then cure it?

          1 reply 0 retweets 1 like
        3. Sarah Constantin‏ @s_r_constantin 25 Aug 2019
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          Replying to @RokoMijicUK

          Gene modifications. Lots of “dwarf” (growth hormone deficient) mammals are long lived, for instance.

          1 reply 0 retweets 0 likes
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