https://s3.amazonaws.com/academia.edu.documents/40947723/Botelho___Cavadas_2015.pdf?response-content-disposition=inline%3B%20filename%3DNeuropeptide_Y_An_Anti-Aging_Player.pdf&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIAIWOWYYGZ2Y53UL3A%2F20190823%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Date=20190823T064017Z&X-Amz-Expires=3600&X-Amz-SignedHeaders=host&X-Amz-Signature=47e9a4eddef9d0d7112873cdeff669d685ab3c1ddcaece513715ae086e51f96d … Neuropeptide Y levels decline with age; Npy-null rodents don't live longer under caloric restriction, while caloric restriction raises Npy levels; Npy-overexpressing rats live longer.
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Some of this is due to aging itself reducing appetite, but a lot is social: poverty, lack of help buying groceries or preparing meals, social isolation, being in an institution with crappy food or staff neglect, etc.
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All the folk-hacks for getting enough nutrition are also clinically validated in the malnourished elderly: tastier & more varied foods, liquid foods, company during meals, assistance acquiring & preparing food, etc. Good news: you don't have to be a doctor to help Grandma eat.
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Anecdotal opinion: the ultimate hack for consuming enough calories while food-repulsed is the milkshake. The cold blunts nausea. Worked for my mom in chemo, worked for me in pregnancy, worked for my ED friend in recovery.
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