https://www.statnews.com/2019/08/01/rotifer-unsung-invertebrate-teaching-us-about-aging/?fbclid=IwAR2ZK1QeUqQ3JAfl50mtLh_-JNK4pd1Jllwsw5KW9xpcX8kyT2C6sWL3zi8 … Rotifers: another invertebrate model organism for aging. Like Daphnia, their phototactic response declines with age.
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Stuff that extends lifespan in rotifers: dietary restriction (by 100%)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004354/ …
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Vitamin E, by 17% (also works in C. elegans, but not in mice): http://sci-hub.tw/https://doi.org/10.1016/0531-5565(84)90036-6 …
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A melatonin-like indole https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010206 … by 300%: similar molecules have been found to extend life in worms, flies, and mice
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Rapamycin, by 37% (also extends life in worms, flies, and mice):https://www.sciencedirect.com/science/article/pii/S0531556514000345 …
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total darkness or short photoperiods (by 22% and 18%; photoperiod affects lifespan in Drosophila too but direction of effect varies with strain);https://www.sciencedirect.com/science/article/pii/053155658490007X …
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Like the rest of us, rotifers show impaired proteostasis and insulin signaling with age:https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3540-x …
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