https://www.statnews.com/2019/08/01/rotifer-unsung-invertebrate-teaching-us-about-aging/?fbclid=IwAR2ZK1QeUqQ3JAfl50mtLh_-JNK4pd1Jllwsw5KW9xpcX8kyT2C6sWL3zi8 … Rotifers: another invertebrate model organism for aging. Like Daphnia, their phototactic response declines with age.
total darkness or short photoperiods (by 22% and 18%; photoperiod affects lifespan in Drosophila too but direction of effect varies with strain);https://www.sciencedirect.com/science/article/pii/053155658490007X …
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Glycerol ( a CR mimetic) and 2-deoxyglucose (a glycolysis inhibitor). https://www.sciencedirect.com/science/article/pii/S0531556514001442 … 2DG also extends life in nematodes but causes increased mortality in rats.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830378/ …
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Nifedipene, a calcium-channel blocker, preserves the phototactic response with age:https://link.springer.com/article/10.1007/BF02432392 …
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Like the rest of us, rotifers show impaired proteostasis and insulin signaling with age:https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3540-x …
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PI3K inhibitor, by 30%: https://sci-hub.tw/10.1007/s10750-005-4244-9 …
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