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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Paul Graham‏Verified account @paulg 12 Jun 2019
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      Brokenness = potential energy. Anything badly broken is a dam holding back a lake of unrealized desires. A startup that can bore a hole through such a dam can liberate all that energy.

      33 replies 211 retweets 1,075 likes
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    2. Paul Graham‏Verified account @paulg 12 Jun 2019
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      The opportunity that comes from brokenness = the number of people affected times how much it hurts them. For example, US higher education is massively broken. In exchange for degrees that are often worthless, millions of people get into debt that will burden them for decades.

      4 replies 18 retweets 154 likes
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    3. Paul Graham‏Verified account @paulg 12 Jun 2019
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      The source of the brokenness of US higher education is a mixture of social custom, institutional rigidity, and government policy that would be extremely hard to unravel. But Lambda School just bored a hole through the dam.

      4 replies 12 retweets 129 likes
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    4. Paul Graham‏Verified account @paulg 12 Jun 2019
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      Lambda School may not be a complete solution to the brokenness of US higher education, but it's an immediate one. And the hole in the dam is still small, but it's growing at startup rates.

      4 replies 11 retweets 160 likes
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    5. Paul Graham‏Verified account @paulg 12 Jun 2019
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      What other problems can be solved by boring a hole through the dam? Could you fix healthcare? On the face of it, it seems unlikely. But I didn't think higher education could be fixed either before I saw Lambda School.

      24 replies 19 retweets 216 likes
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    6. Paul Graham‏Verified account @paulg 12 Jun 2019
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      (I know I'll get hell from trolls for suggesting a startup might fix healthcare. "Tech bro thinks startups can fix all the world's problems." But if I can set off a spark in the brains of a handful of people who might drill through such dams, I'll take that deal.)

      40 replies 22 retweets 351 likes
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    7. Sarah Constantin‏ @s_r_constantin 12 Jun 2019
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      Replying to @paulg

      I currently think aging-prevention drugs (like a statin, except it would cut the risk of multiple age-related diseases like cancer and diabetes in tandem) are the most tractable angle. You don't have to use the medical system for the diseases you don't get.

      2 replies 0 retweets 6 likes
      Sarah Constantin‏ @s_r_constantin 12 Jun 2019
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      Replying to @s_r_constantin @paulg

      The Lambda-school-style approach would be doing something clever with how we pay for healthcare, a financial/software innovation, maybe based on scaling up direct primary care.

      7:10 AM - 12 Jun 2019
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      • Brennen Hodge Lowkey Erudite Scott Leibrand
      1 reply 0 retweets 3 likes
        1. New conversation
        2. Sarah Constantin‏ @s_r_constantin 12 Jun 2019
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          Replying to @s_r_constantin @paulg

          My bias is that scientific problems (how to prevent disease without difficult lifestyle changes) are easier to solve than organizational ones (how to make medical care affordable), but both types of solutions are worth trying.

          1 reply 0 retweets 1 like
        3. Perry E. Metzger‏ @perrymetzger 12 Jun 2019
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          Replying to @s_r_constantin @paulg

          Preventing disease will reduce some costs for sure. For example, the estimate is that about $800B is spent worldwide per annum on Alzheimers. An actual cure would thus have a net present value of about $20Trilion, an astonishing sum.

          2 replies 0 retweets 2 likes
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