Eroom's Law is Moore's Law spelled backwards. It's the bitter name in the pharma industry for the fact that R&D costs per drug have been steadily rising since the 1950's.
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Target discovery, target validation, screening compounds against targets to get hits, in-vitro assays of hit compounds to select leads, lead optimization, preclinical (mouse) studies, and clinical (human) trials. 7 steps, more or less.
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The development of high-throughput screening in the 90's automated the first few and allowed us to test far more molecules in parallel. BUT, the chance that any compound succeeds in clinical trials has been CONSTANT since the 1950's.
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The funnel has been made at least a thousand times larger; initial screens now look at millions of compounds, compared to thousands in the days before HTS.
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