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s_r_constantin's profile
Sarah Constantin
Sarah Constantin
Sarah Constantin
@s_r_constantin

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Sarah Constantin

@s_r_constantin

Math/ML/data-science person now working on solving aging...and helping with COVID19?! Founder, LRI and Daphnia Labs. Married to @oscredwin

Be
srconstantin.posthaven.com
Joined February 2019

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    1. Sarah Constantin‏ @s_r_constantin 1 Jun 2019
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      In drug development, where you have a very long sequence of filters searching for molecules that treat diseases, the most high-leverage way to reduce R&D costs per *successful* drug is to increase the predictive validity of the early screening steps.

      1 reply 2 retweets 13 likes
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    2. Sarah Constantin‏ @s_r_constantin 1 Jun 2019
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      If each stage of testing costs proportionally more (and thus can be applied to proportionally fewer drugs in parallel), each increment of improvement in drug screening accuracy has *exponential* improvements in cost-per-successful-drug-candidate.

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      Sarah Constantin‏ @s_r_constantin 1 Jun 2019
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      Yet, "better drug discovery platforms" are perceived (at least by traditional pharma and clinical-stage biotech investors) as low-value, risky, and unserious. Pharma business development execs I've talked to have said that their companies don't license new screening tech at all!

      7:04 AM - 1 Jun 2019
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        1. Sarah Constantin‏ @s_r_constantin 1 Jun 2019
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          Unless I'm misinformed, this isn't a case where novel screening methods are mistrusted because they have a poor track record.

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        2. Sarah Constantin‏ @s_r_constantin 1 Jun 2019
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          It's true that drug discovery has been trending towards bigger and bigger screens for decades, without reducing R&D costs per successful drug at all. ("Eroom's Law.") But I think this is adequately explained by poor predictive validity.

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        3. Sarah Constantin‏ @s_r_constantin 1 Jun 2019
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          In order to test whether your bigger, cheaper screen will help select better drug candidates, you have to measure its ability to predict outcomes at much later stages of the development process.

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