The most important fact justifying aging/longevity drug discovery is that *lifespan-extending drugs exist.* Lots of them. If you screen 1280 well-known drugs and natural products on nematode worms, 5% of them significantly extend lifespan. https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12163 …
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Worms are very different from people, of course. But 7% of the drugs in the DrugAge database that were reported to extend life in worms were also tested in mice and found to extend life in mice.
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There's unpublished data I've been told about from a very large mouse lifespan study finding again that 5% of drugs tested on mice significantly extended lifespan. (Small sample sizes in each drug group, and fairly small effect sizes, but still remarkable.)
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Replying to @gwern @s_r_constantin
Yes, if they are uncorrected estimates hopefully they are!
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I assume this was corrected, not sure because not published though.
10:27 AM - 20 May 2019
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