The most important fact justifying aging/longevity drug discovery is that *lifespan-extending drugs exist.* Lots of them. If you screen 1280 well-known drugs and natural products on nematode worms, 5% of them significantly extend lifespan. https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12163 …
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IMO screening has potential but the more important thing to do is study the life-span increasing drugs already found and try as hard and with as much genius as you can find to understand the mechanism. If we can find the correlates of anti aging this can speed up trials in rats.
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One of the huge problems is the time delay for studies, but if we can find the correlates and functional mechanics of aging you can even move on to pig and ape studies and get results without needing to wait entire lifespans
End of conversation
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