Metformin protects Daphnia from lethal hypoxic stress: https://www.sciencedirect.com/science/article/pii/S1096495912000723 …
Daphnia has homologues of many of the genes in the insulin receptor pathway (https://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2148-10-305 …): mTOR, FOXO, PTEN, PI3K -- which are famously conserved aging-regulating genes across both invertebrates and vertebrates.
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In other words: evidence is accumulating that Daphnia have the same highly-conserved aging-modulating pathways common to worms, flies, and mice, and that drugs that work on those conserved mechanisms will have similar effects on Daphnia that they do on other animals.
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