Daphnia has homologues of some of the same stress-response and lifespan-regulating genes found in worms, flies, and mammals, such as Sir2 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789591/ …) and Hsp70 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122616/ …)
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Daphnia has homologues of many of the genes in the insulin receptor pathway (https://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2148-10-305 …): mTOR, FOXO, PTEN, PI3K -- which are famously conserved aging-regulating genes across both invertebrates and vertebrates.
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In other words: evidence is accumulating that Daphnia have the same highly-conserved aging-modulating pathways common to worms, flies, and mice, and that drugs that work on those conserved mechanisms will have similar effects on Daphnia that they do on other animals.
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