https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834185/ … Video phenotypic screens for neuroactive drugs in zebrafish; in broad strokes, zebrafish behavior responds to drugs in "predictable" directions. Stimulants speed up motion, anxiolytics slow it down.
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"Behavioral barcoding" clusters drugs according to similar behavioral effects and recovers clusters of drugs with similar chemical structures and mechanisms of action.
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Phenotypic screening picks up some drugs that are bioactive in vivo but not in vitro; i.e. it avoids false negatives from in-vitro screening.
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Out of a 14,000 drug library, 7% caused a change in behavioral barcode with a z-score > 5. Authors don't say how many of these are known neuroactive drugs in mammals.
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Bottom line is that this is evidence video-based, behavioral phenotypic screening adds value. Recapitulates stuff we know from independent sources (similar chemical structures) and adds stuff we don't (bioactivity).
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